Tumor grade improves the prognostic ability of American joint committee on cancer stage in patients with penile carcinoma

Rodolphe Thuret, Maxine Sun, Firas Abdollah, Lars Budaus, Giovanni Lughezzani, Daniel Liberman, Monica Morgan, Rupinder Johal, Claudio Jeldres, Mathieu Latour, Shahrokh F. Shariat, Franois Iborra, Jacques Guiter, Jean Jacques Patard, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Purpose Penile cancer is rare. Thus, predicting cancer specific mortality may be difficult. We devised an accurate and yet easily applicable predictive rule that compares favorably with 2 previous models (73.8% and 74.7% accuracy, respectively). Materials and Methods We identified patients treated with primary tumor excision for all stages of penile squamous cell carcinoma between 1998 and 2006. Disease stage definitions using Surveillance, Epidemiology and End Results stage, American Joint Committee on Cancer stage and TNM classification, and tumor grade were used to predict cancer specific mortality. Predictive accuracy estimates were compared using the DeLong method for related AUCs. Results Surveillance, Epidemiology and End Results stage alone (1 predictor variable) was least accurate (74.5%). American Joint Committee on Cancer stage with tumor grade (2 predictor variables) was the most simple and most accurate (80.9%, p <0.001). A benefit similar to that of American Joint Committee on Cancer stage with tumor grade was seen for TNM classification and TG (80.7%, p = 0.8). However, this rule (4 predictor variables) was more complex than American Joint Committee on Cancer stage and tumor grade. Conclusions American Joint Committee on Cancer stage combined with tumor grade is the simplest, most accurate cancer specific mortality prediction rule after primary tumor excision for penile squamous cell carcinoma. This method is also more accurate than 2 previous cancer specific mortality prediction rules.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalJournal of Urology
Volume185
Issue number2
DOIs
StatePublished - Feb 2011

Bibliographical note

Funding Information:
Supported by the University of Montreal Health Center Urology Specialists , Fonds de la Recherche en Santé du Quebec , University of Montreal Department of Surgery , University of Montreal Health Center Foundation (PIK) and Association Française d'Urologie (RT).

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • carcinoma, squamous cell
  • mortality
  • neoplasm staging
  • nomograms
  • penis

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