Tumor cell mitochondrial matrix/cristae complexes as potential sites for anticancer therapy with polyunsaturated fatty acid analogues

K. M. Anderson, T. Seed, F. Ondrey, D. Wilson, J. E. Harris

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The consequences of incubating human cancer cells with ETYA, a competitive analogue of arachidonic acid, and the reported responses of cells cultured with polyunsaturated fatty acids indicate that polyunsaturated fatty acid analogues or their modified congeners could represent potential cytotoxic anticancer agents. The inner mitochrondrial membrane and matrix may represent important targets for such agents, since they seem unusually susceptible to ETYA-induced oxidative stress.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume40
Issue number2
DOIs
StatePublished - Jun 1990

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