Tryptanthrin derivatives as Toxoplasma gondii inhibitors - Structure-activity-relationship of the 6-position

Bogdana Krivogorsky, Amber C. Nelson, Kelsi A. Douglas, Peter Grundt

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation.

Original languageEnglish (US)
Pages (from-to)1032-1035
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number4
DOIs
StatePublished - Feb 15 2013

Keywords

  • Inhibition of parasite growth
  • Natural product
  • Toxoplasma gondii
  • Tryptanthrin

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