True density of microcrystalline cellulose

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

Microcrystalline cellulose (MCC) exhibits unusual tableting properties, sometimes, inconsistent with its high plasticity. It is found that some of the unusual tableting properties of MCC can be explained in part by the use of inaccurate true density during tableting data analysis. MCC true density as a function of water content is determined using a published method that can determine true density of water containing solids. Results suggest that literature MCC true densities tend to be overestimated as a result of limitations in helium pycnometry.

Original languageEnglish (US)
Pages (from-to)2132-2134
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume94
Issue number10
DOIs
StatePublished - Oct 2005

Keywords

  • Crystallinity
  • Excipients
  • Mechanical properties
  • Powder technology
  • Tableting

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