Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia

Keyphrases

• Acute Myeloid Leukemia 100%
• Cytosine 100%
• Trp53 100%
• In Vitro Selection 100%
• Cytarabine Resistance 100%
• Cytarabine 75%
• Resistant Lines 25%
• Chemoresistance 25%
• P53 Protein 25%
• Pifithrin-α 25%
• P21Cip1 25%
• Molecular Mechanism 12%
• Loss Function 12%
• Genetic Approach 12%
• Apoptosis Induction 12%
• Chemotherapy 12%
• Complementary DNA (cDNA) 12%
• Protein Activity 12%
• Ara-C 12%
• Genetic Mechanism 12%
• Molecular Changes 12%
• Protein Level 12%
• Leukemia Therapy 12%
• Leukemia Cell Lines 12%
• DNA-binding Domain 12%
• Protein Accumulation 12%
• Dominant Negative 12%
• Bcl-xL 12%
• Genomic Deletion 12%
• Transactivation 12%
• Retroviral Transduction 12%
• Acute Myeloid Leukemia Cells 12%
• Parental Lines 12%
• Exon 4 12%
• Cleaved caspase-3 12%
• Inpatient Treatment 12%
• Relapsed Acute Myeloid Leukemia 12%

Biochemistry, Genetics and Molecular Biology

• Myeloid 100%
• in Vitro Selection 100%
• Cytarabine 100%
• Murine 11%
• P53 11%
• Drug Resistance 11%
• Messenger RNA 11%
• Exon 5%
• DNA-binding Domain 5%
• Transactivation 5%
• Genetic Mechanism 5%
• Genetic Approach 5%
• Caspase 3 5%
• Genomics 5%
• Programmed Cell Death 5%
• Molecular Mechanism 5%