Troponin T, NT-proBNP, and venous thromboembolism: The longitudinal investigation of thromboembolism etiology (LITE)

Aaron R. Folsom, Pamela L. Lutsey, Vijay Nambi, Christopher R. Defilippi, Susan R. Heckbert, Mary Cushman, Christie M. Ballantyne

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Increased levels of plasma troponins and natriuretic peptides are markers of cardiac dysfunction associated with increased risk of cardiovascular disease. Little information exists on cardiac dysfunction and occurrence of venous thromboembolism (VTE). In two prospective epidemiological cohorts, we tested the hypothesis that high-sensitivity troponin T (TnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) are associated positively with VTE occurrence. The Atherosclerosis Risk in Communities (ARIC) study and the Cardiovascular Health Study (CHS) measured plasma TnT and NT-proBNP in 13,719 men or women with no history of venous thrombosis, coronary heart disease, or heart failure and followed them for approximately 10 years for VTE occurrence (n=348 VTEs). In both ARIC and CHS, TnT was associated positively with incidence of total VTE and provoked VTE, but not with unprovoked VTE: age, race, and sex-adjusted hazard ratios for total VTE in the pooled analysis were 1.00, 0.85, 1.36, 1.51, and 1.98 (p-trend <0.0001) across five categories of TnT. In contrast, the association of NT-proBNP with VTE was positive in ARIC (hazard ratios approximately 2.5-fold for the highest versus lowest NT-proBNP quintiles), but non-existent in CHS.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalVascular Medicine (United Kingdom)
Volume19
Issue number1
DOIs
StatePublished - Feb 2014

Keywords

  • natriuretic peptides
  • pulmonary embolism
  • troponins
  • venous thrombosis

Fingerprint

Dive into the research topics of 'Troponin T, NT-proBNP, and venous thromboembolism: The longitudinal investigation of thromboembolism etiology (LITE)'. Together they form a unique fingerprint.

Cite this