Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca2+-dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.
|Original language||English (US)|
|Number of pages||4|
|Journal||News in Physiological Sciences|
|State||Published - Dec 2001|