TY - JOUR
T1 - Troponin I isoforms and chimeras
T2 - Tuning the molecular switch of cardiac contraction
AU - Westfall, Margaret V.
AU - Metzger, Joseph M.
PY - 2001/12
Y1 - 2001/12
N2 - Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca2+-dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.
AB - Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca2+-dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.
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U2 - 10.1152/physiologyonline.2001.16.6.278
DO - 10.1152/physiologyonline.2001.16.6.278
M3 - Article
C2 - 11719605
AN - SCOPUS:0035653571
SN - 0886-1714
VL - 16
SP - 278
EP - 281
JO - News in Physiological Sciences
JF - News in Physiological Sciences
IS - 6
ER -