Troponin I isoforms and chimeras: Tuning the molecular switch of cardiac contraction

Margaret V. Westfall, Joseph M. Metzger

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca2+-dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalNews in Physiological Sciences
Volume16
Issue number6
DOIs
StatePublished - Dec 2001

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