tRNA and cytochrome c in cell death and beyond

Yide Mei, Jeongsik Yong, Aaron Stonestrom, Xiaolu Yang

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Both transfer RNA (tRNA) and cytochrome c are essential to cellular function: tRNA mediates protein synthesis while cytochrome c is required for oxidative phosphorylation and apoptosis induction. tRNA has recently been implicated as a direct regulator of the well-conserved apoptotic role of cytochrome c. Interaction between these molecules could potentially coordinate biosynthesis, energy production and apoptosis. Here we review the diversity and dynamics of tRNA and how this class of non-coding RNAs may regulate the role of cytochrome c in apoptosis. We comment on unanswered questions in the cell biology of this interaction and how answers may influence our understanding of disease.

Original languageEnglish (US)
Pages (from-to)3008-3011
Number of pages4
JournalCell Cycle
Issue number15
StatePublished - Aug 1 2010

Bibliographical note

Funding Information:
We thank Lili Guo for designing the figure. Supported by NIH grants GM60911 and CA108872 to X.Y.


  • Apoptosis
  • Cancer
  • Caspase
  • Cytochrome c
  • Mitochondria
  • Protein synthesis
  • tRNA


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