Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Casey R. Dorr, Sergiy V Yemets, Oksana N Kolomitsyna, Pavel Krasutsky, Louis M Mansky

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

Original languageEnglish (US)
Pages (from-to)542-545
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Antiretroviral
  • Antiviral
  • Protease
  • Proteolysis
  • Retrovirus

Fingerprint Dive into the research topics of 'Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication'. Together they form a unique fingerprint.

Cite this