Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Casey R. Dorr; Sergiy V Yemets; Oksana N Kolomitsyna; Pavel Krasutsky; Louis M Mansky

doi:10.1016/j.bmcl.2010.10.078

Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Casey R. Dorr, Sergiy V Yemets, Oksana N Kolomitsyna, Pavel Krasutsky, Louis M Mansky

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

Original language	English (US)
Pages (from-to)	542-545
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.078
State	Published - Jan 1 2011

Bibliographical note

Funding Information:
Supported by the Continuing Umbrella of Research Experiences Supplement to NIH T32 CA09138 (Cancer Biology Training Grant) (to CDR), NIH Supplement to NIH GM56615 to Promote Diversity in Health-Related Research (to CDR), and a Natural Resources Research Institute funding agreement.

Keywords

Antiretroviral
Antiviral
Protease
Proteolysis
Retrovirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.",

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AU - Yemets, Sergiy V

AU - Kolomitsyna, Oksana N

AU - Krasutsky, Pavel

AU - Mansky, Louis M

N1 - Funding Information: Supported by the Continuing Umbrella of Research Experiences Supplement to NIH T32 CA09138 (Cancer Biology Training Grant) (to CDR), NIH Supplement to NIH GM56615 to Promote Diversity in Health-Related Research (to CDR), and a Natural Resources Research Institute funding agreement.

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N2 - Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

AB - Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

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KW - Antiviral

KW - Protease

KW - Proteolysis

KW - Retrovirus

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Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Abstract

Bibliographical note

Keywords

UN SDGs

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