Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Casey R. Dorr, Sergiy V Yemets, Oksana N Kolomitsyna, Pavel Krasutsky, Louis M Mansky

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

Original languageEnglish (US)
Pages (from-to)542-545
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
StatePublished - Jan 1 2011

Bibliographical note

Funding Information:
Supported by the Continuing Umbrella of Research Experiences Supplement to NIH T32 CA09138 (Cancer Biology Training Grant) (to CDR), NIH Supplement to NIH GM56615 to Promote Diversity in Health-Related Research (to CDR), and a Natural Resources Research Institute funding agreement.


  • Antiretroviral
  • Antiviral
  • Protease
  • Proteolysis
  • Retrovirus


Dive into the research topics of 'Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication'. Together they form a unique fingerprint.

Cite this