Abstract
Ulcerative colitis (UC), which affects millions of people worldwide, is characterized by extensive colonic injury involving mucosal and submucosal layers of the colon. Nuclear factor E2‐ related factor 2 (Nrf2) plays a critical role in cellular protection against oxidant‐induced stress. An-tioxidant response element (ARE) is the binding site recognized by Nrf2 and leads to the expression of phase II detoxifying enzymes and antioxidant proteins. The Nrf2/ARE system is a key factor for preventing and resolving tissue injury and inflammation in disease conditions such as UC. Re-searchers have proposed that both Keap1‐dependent and Keap1‐independent cascades contribute positive effects on activation of the Nrf2/ARE pathway. In this review, we summarize the present knowledge on mechanisms controlling the activation process. We will further review nutritional compounds that can modulate activation of the Nrf2/ARE pathway and may be used as potential therapeutic application of UC. These comprehensive data will help us to better understand the Nrf2/ARE signaling pathway and promote its effective application in response to common diseases induced by oxidative stress and inflammation.
| Original language | English (US) |
|---|---|
| Article number | 11411 |
| Journal | International journal of molecular sciences |
| Volume | 22 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 1 2021 |
Bibliographical note
Funding Information:This research was funded by the National Natural Science Foundation of China, grant number 32102587, 31930106 and 31829004; the National Ten‐thousand Talents Program of China, grant number 23070201; the 2115 Talent Development Program of China Agricultural University, grant number 1041‐00109019; and the 111 Project, grant number B16044.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Antioxidant response element
- Kelch‐like ECH‐associated protein 1
- Nuclear factor E2‐ related factor 2
- Nutritional regulation
- Ulcerative colitis