Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn; Masayoshi Arai; Naoyuki Kotoku; Catherine Vilchze; Anthony D. Baughn; Prashini Moodley; William R. Jacobs; Motomasa Kobayashi

doi:10.1016/j.bmcl.2010.04.100

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilchze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs, Motomasa Kobayashi

Microbiology

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

Original language	English (US)
Pages (from-to)	3658-3663
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.100
State	Published - 2010

Bibliographical note

Funding Information:
The authors thank Ms. Salona Moodley, Mr. Yushir R. Maharaj, Ms. Karnishree Govender (University of KwaZulu Natal) for excellent technical assistance. A.D.B. was supported by a Grant from the Helen Hay Whitney Foundation . This study was financially supported by the Hoh-ansha Foundation , the Uehara Memorial Foundation , JSPS-South Africa (NRF) Joint Research Program , and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan .

Keywords

Aminolipopeptide
Anti-mycobacterial activity
Dormant
Trichoderin
Trichoderma sp.
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2010.04.100

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title = "Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria",

abstract = "Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.",

keywords = "Aminolipopeptide, Anti-mycobacterial activity, Dormant, Trichoderin, Trichoderma sp., Tuberculosis",

author = "Patamaporn Pruksakorn and Masayoshi Arai and Naoyuki Kotoku and Catherine Vilchze and Baughn, {Anthony D.} and Prashini Moodley and Jacobs, {William R.} and Motomasa Kobayashi",

note = "Funding Information: The authors thank Ms. Salona Moodley, Mr. Yushir R. Maharaj, Ms. Karnishree Govender (University of KwaZulu Natal) for excellent technical assistance. A.D.B. was supported by a Grant from the Helen Hay Whitney Foundation . This study was financially supported by the Hoh-ansha Foundation , the Uehara Memorial Foundation , JSPS-South Africa (NRF) Joint Research Program , and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan .",

year = "2010",

doi = "10.1016/j.bmcl.2010.04.100",

language = "English (US)",

volume = "20",

pages = "3658--3663",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

AU - Pruksakorn, Patamaporn

AU - Arai, Masayoshi

AU - Kotoku, Naoyuki

AU - Vilchze, Catherine

AU - Baughn, Anthony D.

AU - Moodley, Prashini

AU - Jacobs, William R.

AU - Kobayashi, Motomasa

N1 - Funding Information: The authors thank Ms. Salona Moodley, Mr. Yushir R. Maharaj, Ms. Karnishree Govender (University of KwaZulu Natal) for excellent technical assistance. A.D.B. was supported by a Grant from the Helen Hay Whitney Foundation . This study was financially supported by the Hoh-ansha Foundation , the Uehara Memorial Foundation , JSPS-South Africa (NRF) Joint Research Program , and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan .

PY - 2010

Y1 - 2010

N2 - Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

AB - Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

KW - Aminolipopeptide

KW - Anti-mycobacterial activity

KW - Dormant

KW - Trichoderin

KW - Trichoderma sp.

KW - Tuberculosis

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ER -

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Abstract

Bibliographical note

Keywords

UN SDGs

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