Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilchze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs, Motomasa Kobayashi

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

Original languageEnglish (US)
Pages (from-to)3658-3663
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number12
DOIs
StatePublished - 2010

Keywords

  • Aminolipopeptide
  • Anti-mycobacterial activity
  • Dormant
  • Trichoderin
  • Trichoderma sp.
  • Tuberculosis

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