Triazoxins: Novel nucleosides with anti-Giardia activity

Praveen K. Pogula, Atasi De Chatterjee, Miguel Chi, Harrison W. VanKoten, Siddhartha Das, Steven E. Patterson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Novel nucleoside analogues named “triazoxins” were synthesized. Of these, two analogues were found to be highly effective against Giardia lamblia, an intestinal parasite and a major cause of waterborne infection, worldwide. While compound 7 reduced the growth of trophozoites in culture (IC50, ~5 μM), compound 21 blocked the in vitro cyst production (IC50 ~5 μM). Compound 21 was also effective against trophozoites (IC50, ~36 μM). A third analogue (compound 8) was effective against both trophozoites (IC50, ~36 μM) and cysts (IC50, ~20 μM) although at higher concentration. Thus triazoxin analogues are unique and exhibit morphology (i.e., trohozoites or cysts) -specific effects against Giardia.

Original languageEnglish (US)
Article number127175
JournalBioorganic and Medicinal Chemistry Letters
Issue number12
StatePublished - Jun 15 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd


  • Anti-giardiasis
  • Cyst
  • Giardia
  • Phosphonoxin
  • Triazoxin
  • Trophozoite


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