Trends and outcomes of pulmonary arterial hypertension–related hospitalizations in the United States: Analysis of the nationwide inpatient sample database from 2001 through 2012

Vidhu Anand, Samit S. Roy, Stephen L. Archer, E. Kenneth Weir, Sushil Kumar Garg, Sue Duval, Thenappan Thenappan

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58 Scopus citations


IMPORTANCE: Recent trends and outcomes of pulmonary arterial hypertension (PAH)–related hospitalization in adults in the United States are unknown. OBJECTIVE: To examine the characteristics of PAH-related hospitalizations. DESIGN, SETTING, AND PARTICIPANTS: We analyzed the National Inpatient Sample database for all adult patients (≥18 years old) with PAH as the principal discharge diagnosis from January 1, 2001, through December 31, 2012. MAIN OUTCOMES AND MEASURES: We analyzed the temporal trends in hospitalization rate, hospital charges, in-hospital mortality, length of hospitalization, and comorbidities pertaining to PAH-related hospitalizations. We also evaluated the predictors of in-hospital mortality and length of hospitalizations. RESULTS: The number of PAH-related hospitalizations per year in adults decreased significantly from 2001 through 2012 (3177 vs 1345, P for trend <.001). However, the mean hospital charge per admission increased 2.7-fold from 2001 through 2012 ($29 507 vs $79 607, P for trend <.001). There was a significant increase in each of these associated comorbid conditions: diabetes (4.6%-7.8%), hypertension (5.1%-17.1%), coronary artery disease (15.6%-22.3%), chronic obstructive pulmonary disease (14.4%-20.1%), anemia (12.4%-20.4%), cardiac dysrhythmias (21.7%-29.0%), congestive heart failure (40.7%-56.1%), acute (5.9%-20.1%) or chronic kidney disease (1.1%-16.4%), fluid and electrolyte imbalance (18.9%-35.3%), pneumonia (4.4%-6.3%), cardiogenic shock (0.5%-1.5%), and acute respiratory failure (4.3%-20.8%) from 2001 through 2012. The length of hospitalization increased (mean [SE], 7.0 [0.5] days in 2001 vs 7.6 [0.6] days in 2012, P for trend = .009), but in-patient mortality remained unchanged (7.8% [1.1%] in 2001 vs 6.3% [1.7%] in 2012, P for trend = .54). Admission to a teaching hospital (β coefficient for length of hospitalization, 2.0; 95% CI, 1.3-1.6; odds ratio [OR] for mortality, 1.5; 95% CI, 1.1-2.1), cardiac dysrhythmias (β coefficient, 1.8; 95% CI, 1.1-2.6; OR, 1.8; 95% CI, 1.4-2.4), acute kidney injury (β coefficient, 5.0; 95% CI, 3.9-6.1; OR, 2.3; 95% CI, 1.7-3.2), acute cerebrovascular accident (β coefficient, 6.6; 95% CI, 1.9-11.3; OR, 6.7; 95% CI, 2.1-21.1), and acute respiratory failure (β coefficient, 6.2; 95% CI, 5.1-7.4; OR, 5.6; 95% CI, 4.2-7.5) were associated with increased length of hospitalization and in-hospital mortality. Congestive heart failure (OR, 1.7; 95% CI, 1.3-2.2), cardiogenic shock (OR, 5.4; 95% CI, 2.7-10.9), and fluid and electrolyte imbalance (OR, 1.9; 95% CI, 1.5-2.4) were associated with increased in-hospital mortality but not length of hospitalization. CONCLUSIONS AND RELEVANCE: Analyses of temporal changes in PAH care reveal a significant decrease in PAH-related hospitalizations in the United States, but hospital charges have increased substantially and are increasingly being borne by Medicare. In-hospital mortality remains unchanged, but length of hospitalization has increased. This study should help identify the characteristics of patients with PAH that are associated with increased risk of in-hospital mortality and longer length of hospitalization.

Original languageEnglish (US)
Pages (from-to)1021-1029
Number of pages9
JournalJAMA cardiology
Issue number9
StatePublished - Dec 2016

Bibliographical note

Funding Information:
Funding/Support: This study was supported by scientist development grant 15SDG25560048 from the American Heart Association and a High Risk and High Reward grant from the Lillehei Heart Institute (Dr Thenappan) and by a grant from the Canadian Institutes of Health Research Foundation, grants NIH-RO1-HL071115 and 1RC1HL099462 from the National Institutes of Health, Tier 1 Canada Research Chair in Mitochondrial Dynamics funding, and the William J. Henderson Foundation (Dr Archer).

Publisher Copyright:
Copyright 2016 American Medical Association. All rights reserved.


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