Tregs served sunny-side up

Brian C. Betts, James W. Young

Research output: Contribution to journalComment/debatepeer-review


In this issue of Blood, Bastien and colleagues demonstrate that photopheresis purges donor T cells proliferating against host alloantigens in patients with GVHD after HSCT.1 Photodepletion of these alloreactive lymphocytes concomitantly preserves and expands Tregs, which when reinfused into patients with treatment-refractory chronic GVHD, survive in vivo and correlate with positive clinical responses.

Original languageEnglish (US)
Pages (from-to)4736-4737
Number of pages2
Issue number23
StatePublished - Dec 2 2010
Externally publishedYes


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