TY - JOUR
T1 - Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
AU - Prisco, Sasha Z.
AU - Thenappan, Thenappan
AU - Prins, Kurt W.
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV. Although there are shared molecular mechanisms in both RV and left ventricle (LV) dysfunction, there are important differences between the 2 ventricles that may allow for the development of RV-enhancing or RV-directed therapies. In this review, we discuss the current understandings of the dysregulated pathways that promote RV dysfunction, highlight RV-enriched or RV-specific pathways that may be of particular therapeutic value, and summarize recent and ongoing clinical trials that are investigating RV function in PAH. It is hoped that development of RV-targeted therapies will improve quality of life and enhance survival for this deadly disease.
AB - Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV. Although there are shared molecular mechanisms in both RV and left ventricle (LV) dysfunction, there are important differences between the 2 ventricles that may allow for the development of RV-enhancing or RV-directed therapies. In this review, we discuss the current understandings of the dysregulated pathways that promote RV dysfunction, highlight RV-enriched or RV-specific pathways that may be of particular therapeutic value, and summarize recent and ongoing clinical trials that are investigating RV function in PAH. It is hoped that development of RV-targeted therapies will improve quality of life and enhance survival for this deadly disease.
KW - clinical trials
KW - pulmonary arterial hypertension
KW - right ventricle
UR - http://www.scopus.com/inward/record.url?scp=85097756660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097756660&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2020.07.011
DO - 10.1016/j.jacbts.2020.07.011
M3 - Review article
C2 - 33426379
AN - SCOPUS:85097756660
SN - 2452-302X
VL - 5
SP - 1244
EP - 1260
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 12
ER -