Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels

Fernanda Salles; Andrea Bacellar; Mirla Amorim; Glória Orge; Michael Sundberg; Márcia Lima; Silvane Santos; Aurélia Porto; Edgar Carvalho

doi:10.1093/trstmh/trt052

Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels

Fernanda Salles
, Andrea Bacellar
, Mirla Amorim
, Glória Orge
, Michael Sundberg
, Márcia Lima
, Silvane Santos
, Aurélia Porto
, Edgar Carvalho

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.

Original language	English (US)
Article number	trt052
Pages (from-to)	526-529
Number of pages	4
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	107
Issue number	8
DOIs	https://doi.org/10.1093/trstmh/trt052
State	Published - Aug 2013
Externally published	Yes

Bibliographical note

Funding Information:
Funding: This work was supported by the NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundac¸ão de Amparo a Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ATLL
HTLV-1
Interleukin-2 receptor
Leukemia
SIL-2R
Strongyloides stercoralis

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10.1093/trstmh/trt052

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Salles, F., Bacellar, A., Amorim, M., Orge, G., Sundberg, M., Lima, M., Santos, S., Porto, A., & Carvalho, E. (2013). Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels. Transactions of the Royal Society of Tropical Medicine and Hygiene, 107(8), 526-529. Article trt052. https://doi.org/10.1093/trstmh/trt052

Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels. / Salles, Fernanda; Bacellar, Andrea; Amorim, Mirla et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 107, No. 8, trt052, 08.2013, p. 526-529.

Research output: Contribution to journal › Article › peer-review

Salles, F, Bacellar, A, Amorim, M, Orge, G, Sundberg, M, Lima, M, Santos, S, Porto, A & Carvalho, E 2013, 'Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 107, no. 8, trt052, pp. 526-529. https://doi.org/10.1093/trstmh/trt052

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abstract = "Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.",

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author = "Fernanda Salles and Andrea Bacellar and Mirla Amorim and Gl{\'o}ria Orge and Michael Sundberg and M{\'a}rcia Lima and Silvane Santos and Aur{\'e}lia Porto and Edgar Carvalho",

note = "Funding Information: Funding: This work was supported by the NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundac¸{\~a}o de Amparo a Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq.",

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doi = "10.1093/trstmh/trt052",

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AU - Salles, Fernanda

AU - Bacellar, Andrea

AU - Amorim, Mirla

AU - Orge, Glória

AU - Sundberg, Michael

AU - Lima, Márcia

AU - Santos, Silvane

AU - Porto, Aurélia

AU - Carvalho, Edgar

N1 - Funding Information: Funding: This work was supported by the NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundac¸ão de Amparo a Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq.

PY - 2013/8

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N2 - Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.

AB - Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.

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KW - HTLV-1

KW - Interleukin-2 receptor

KW - Leukemia

KW - SIL-2R

KW - Strongyloides stercoralis

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Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels

Abstract

Bibliographical note

UN SDGs

Keywords

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