Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels

Fernanda Salles, Andrea Bacellar, Mirla Amorim, Glória Orge, Michael Sundberg, Márcia Lima, Silvane Santos, Aurélia Porto, Edgar Carvalho

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.

Original languageEnglish (US)
Article numbertrt052
Pages (from-to)526-529
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume107
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • ATLL
  • HTLV-1
  • Interleukin-2 receptor
  • Leukemia
  • SIL-2R
  • Strongyloides stercoralis

Fingerprint Dive into the research topics of 'Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased tnfα and decreased soluble IL2 receptor levels'. Together they form a unique fingerprint.

  • Cite this