Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods: We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion: These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.
|Original language||English (US)|
|Number of pages||4|
|Journal||Transactions of the Royal Society of Tropical Medicine and Hygiene|
|State||Published - Aug 2013|
Bibliographical noteFunding Information:
Funding: This work was supported by the NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundac¸ão de Amparo a Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq.
- Interleukin-2 receptor
- Strongyloides stercoralis