Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease

Krista M. Newman, Kevin M. Rank, Byron P. Vaughn, Alexander Khoruts

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss several challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalGut microbes
DOIs
StatePublished - May 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis

Keywords

  • Crohn's disease
  • clostridium difficile
  • fecal microbiota transplantation
  • inflammatory bowel disease
  • ulcerative colitis

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