Abstract
Pharmacologic treatment of peripheral neuropathies is challenging and has largely been effective only for immune-mediated neuropathies. Although animal models of immunemediated neuropathies have provided insight into pathophysiology, our understanding of initiating and perpetuating immune factors remains incomplete. Most drugs used for immune-mediated neuropathies were originally developed for connective tissue diseases. There are few randomized controlled trials for neuropathies, and most data on efficacy are from case series. Despite these limitations, there are useful empiric data on dosing, efficacy, and side effects for a range of immunomodulating and immunosuppressing agents. This chapter reviews how to use commonly prescribed agents, focusing on dosing, pharmacokinetics, and dynamics, and side effects. The indications for use are briefly reviewed; detailed discussions of specific indications are contained in the relevant chapters.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Peripheral Neuropathy |
| Publisher | CRC Press |
| Pages | 639-656 |
| Number of pages | 18 |
| ISBN (Electronic) | 9780849354861 |
| ISBN (Print) | 9780824754327 |
| State | Published - Jan 1 2005 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2005 by Taylor & Francis Group, LLC.