Treatment of dyslipidemia in allogeneic hematopoietic stem cell transplant patients

Bernard Lawrence Marini, Sung Won Choi, Craig Alan Byersdorfer, Simon Cronin, David G. Frame

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

As survival rates in allogeneic hematopoietic stem cell transplantation (HSCT) continue to improve, attention to long-term complications, including cardiovascular disease, becomes a major concern. Cardiovascular diseaseand dyslipidemia are a common, yet often overlooked occurrence post-HSCT that results in significant morbidity and mortality. Also, increasing evidence shows that several anti-hyperlipidemia medications, the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in particular, may have a role in modulating graft-versus-host disease (GVHD). However, factors such as drug-drug interactions, adverse effect profiles, and the relative efficacy in lowering cholesterol and triglyceride levels must be taken into account when choosing safe and effective lipid-lowering therapy in this setting. This review seeks to provide guidance to the clinician in the management of dyslipidemia in the allogeneic HSCT population, taking into account the recently published American College of Cardiology/American Heart Association guidelines on hyperlipidemia management, special considerations in this challenging population, and the evidence for each agent's potentialrole in modulating GVHD.

Original languageEnglish (US)
Pages (from-to)809-820
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.

Keywords

  • Allogeneic transplantation
  • Dyslipidemia
  • Graft-versus-host disease
  • Late complications
  • Statins

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