TREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID

John F. Kessler, Norman Levine, Frank L. Meyskens, Peter J. Lynch, Stephen E. Jones

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Four patients with refractory cutaneous T-cell lymphoma (mycosis fungoides) were treated with 13-cis-retinoic acid. Near complete clearing of extensive tumours and plaques was seen in one patient, who remains in partial remission with continued improvement after fifteen months. Two patients showed improvement in pruritus and 50% reduction in plaques by four and six weeks, respectively. The fourth patient had improvement in pruritus and clearing of plaques, but dryness and scaling necessitated reduction and eventually withdrawal of the treatment.

Original languageEnglish (US)
Pages (from-to)1345-1347
Number of pages3
JournalThe Lancet
Volume321
Issue number8338
DOIs
StatePublished - Jun 18 1983

Bibliographical note

Funding Information:
This work was supported by grants from the NIH (CA 27502, CA 23074, CA 17094) and Hoffman-LaRoche, Inc.

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