TY - JOUR
T1 - Treatment of chorea associated with Huntington's disease
T2 - Focus on tetrabenazine
AU - Setter, Stephen M.
AU - Neumiller, Joshua J.
AU - Dobbins, Erin K.
AU - Wood, Lindy
AU - Clark, Jeffrey
AU - DuVall, Cristina A.K.
AU - Santiago, Anthony J
PY - 2009/7
Y1 - 2009/7
N2 - Objective: Review Huntington's disease (HD) and the role of tetrabenazine (TBZ) in treating chorea associated with this disease. Discuss the pharmacology, side-effect profile, drug interactions, precautions, and contraindications of TBZ. Data Sources: Literature identified within MEDLINE and PubMED. Study Selection: Two manuscripts specifically regarding the management of chorea in patients with HD were identified. Additionally, studies involving the clinical use of TBZ were reviewed. Data Synthesis: The literature identified provided information regarding the efficacy, safety, and pharmacological actions of TBZ. Conclusion: HD is often accompanied by chorea, and the treatment with TBZ in this patient population often results in decreased chorea. Pharmacists managing patients on TBZ need to be well versed in TBZ's potential side effects, drug interactions, and unique dosing considerations.
AB - Objective: Review Huntington's disease (HD) and the role of tetrabenazine (TBZ) in treating chorea associated with this disease. Discuss the pharmacology, side-effect profile, drug interactions, precautions, and contraindications of TBZ. Data Sources: Literature identified within MEDLINE and PubMED. Study Selection: Two manuscripts specifically regarding the management of chorea in patients with HD were identified. Additionally, studies involving the clinical use of TBZ were reviewed. Data Synthesis: The literature identified provided information regarding the efficacy, safety, and pharmacological actions of TBZ. Conclusion: HD is often accompanied by chorea, and the treatment with TBZ in this patient population often results in decreased chorea. Pharmacists managing patients on TBZ need to be well versed in TBZ's potential side effects, drug interactions, and unique dosing considerations.
KW - Chorea
KW - Huntington's disease
KW - Tetrabenazine
UR - http://www.scopus.com/inward/record.url?scp=67650936053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650936053&partnerID=8YFLogxK
U2 - 10.4140/TCP.n.2009.524
DO - 10.4140/TCP.n.2009.524
M3 - Review article
C2 - 19689181
AN - SCOPUS:67650936053
SN - 0888-5109
VL - 24
SP - 524
EP - 537
JO - Consultant Pharmacist
JF - Consultant Pharmacist
IS - 7
ER -
