TY - JOUR
T1 - Treatment of aregeneratoric anemia following an ABO-incompatible allogeneic peripheral blood stem cell transplantation
T2 - A case report
AU - Üstün, Celalettin
AU - Çelebi, Harika
AU - Arat, Mutlu
AU - Özcan, Muhit
AU - Dilek, Imdat
AU - Gürman, Günhan
AU - Demirer, Taner
AU - Ilhan, Osman
AU - Keskin, Remzi
AU - Koç, Haluk
PY - 1999
Y1 - 1999
N2 - Aregeneratoric anemia (AA) occurs rarely after ABO-incompatible allogeneic peripheral blood stem cell transplantation (alloPBSCT), and its management is generally difficult. Here, we present a 31-year-old white man with myelodysplastic syndrome who developed AA after receiving stem cells from his human leukocyte antigen (HLA) identical, but ABO-incompatible sibling. Because his anti-A antibody titers were high, therapy with conventional doses of erythropoietin and prednisolone failed to treat the AA. Following 8 cycles of plasma exchange and higher doses of erythropoietin and prednisolone as well as danazol administration, anti-A titers decreased, and his anemia improved significantly. In conclusion, to treat and obtain a low titer of antibodies in a patient with AA following an ABO-incompatible alloPBSCT, higher doses of erythropoietin and corticosteroids associated with plasma exchange have to be used.
AB - Aregeneratoric anemia (AA) occurs rarely after ABO-incompatible allogeneic peripheral blood stem cell transplantation (alloPBSCT), and its management is generally difficult. Here, we present a 31-year-old white man with myelodysplastic syndrome who developed AA after receiving stem cells from his human leukocyte antigen (HLA) identical, but ABO-incompatible sibling. Because his anti-A antibody titers were high, therapy with conventional doses of erythropoietin and prednisolone failed to treat the AA. Following 8 cycles of plasma exchange and higher doses of erythropoietin and prednisolone as well as danazol administration, anti-A titers decreased, and his anemia improved significantly. In conclusion, to treat and obtain a low titer of antibodies in a patient with AA following an ABO-incompatible alloPBSCT, higher doses of erythropoietin and corticosteroids associated with plasma exchange have to be used.
KW - ABO mismatch
KW - Allogeneic peripheral blood stem cell transplantation
KW - Aregeneratoric anemia
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U2 - 10.1046/j.1526-0968.1999.00135.x
DO - 10.1046/j.1526-0968.1999.00135.x
M3 - Article
C2 - 10427629
AN - SCOPUS:6544243897
SN - 1744-9979
VL - 3
SP - 275
EP - 277
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
IS - 3
ER -