Treatment of ANCA-associated vasculitis: New therapies and a look at old entities

Ladan Zand, Ulrich Specks, Sanjeev Sethi, Fernando C. Fervenza

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small-vessel vasculitis that primarily comprises 2 clinical syndromes: granulomatosis with polyangiitis and microscopic polyangiitis. Cyclophosphamide and glucocorticoids have traditionally been used for induction of remission. However, more recent studies have shown that rituximab is as effective as cyclophosphamide for induction therapy in patients with newly diagnosed severe AAV and superior for patients with relapsing AAV. There is also accumulating evidence indicating a potential role of rituximab for maintenance therapy in AAV. In this article, we will review the evidence supporting the various treatment choices for patients with AAV.

Original languageEnglish (US)
Pages (from-to)182-193
Number of pages12
JournalAdvances in Chronic Kidney Disease
Issue number2
StatePublished - Mar 1 2014
Externally publishedYes

Bibliographical note

Funding Information:
Support: F.C.F. received unrestricted research grants from Genentech/Roche (maker of rituximab); U.S. received money from Genentech/Roche for research grant and consulting (money to institution); L.Z. and S.S. have no relevant financial interests.


  • ANCA-associated vasculitis
  • Cyclophosphamide
  • Rituximab


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