Malignant ovarian neoplasms associated with pregnancy are uncommon, and the majority of these are Stage I. While adjuvant chemotherapy for germ cell tumors during pregnancy has been reported, only one previous report exists on the use of cisplatin-based chemotherapy for epithelial ovarian carcinomas during pregnancy. A patient with Stage III cystadenocarcinoma of the ovary treated during pregnancy with five courses of dose-intensive cisplatin and cyclophosphamide is presented. No adverse fetal effects secondary to cisplatin-based chemotherapy were noted. A review of the literature is presented.