Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

Can Cheng, Songming Zhuo, Bo Zhang, Xu Zhao, Ying Liu, Chaoliang Liao, Jing Quan, Zhenzhen Li, Ann M. Bode, Ya Cao, Xiangjian Luo

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Metabolic disorders can lead to a scarcity or excess of certain metabolites such as glucose, lipids, proteins, purines, and metal ions, which provide the biochemical foundation and directly contribute to the etiology of metabolic diseases. Nonalcoholic fatty liver disease, obesity, and cancer are common metabolic disorders closely associated with abnormal lipid metabolism. In this review, we first describe the regulatory machinery of lipid metabolism and its deregulation in metabolic diseases. Next, we enumerate and integrate the mechanism of action of some natural compounds, including terpenoids and flavonoids, to ameliorate the development of metabolic diseases by targeting lipid metabolism. Medicinal natural products have an established history of use in health care and therapy. Natural compounds might provide a good source of potential therapeutic agents for treating or preventing metabolic diseases with lipid metabolic abnormalities.

Original languageEnglish (US)
Pages (from-to)1654-1663
Number of pages10
JournalInternational Journal of Biological Sciences
Volume15
Issue number8
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (81874195, 81573014), the Natural Science Foundation of Hunan Province (2016JJ2171).

Publisher Copyright:
© Ivyspring International Publisher.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Cancer
  • Lipid metabolism
  • Natural compound
  • Nonalcoholic fatty liver disease
  • Obesity

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