Treating heart failure with enhanced external counterpulsation (EECP): Design of the prospective evaluation of EECP in heart failure (PEECH) trial

Arthur M. Feldman, Marc A. Silver, Gary S. Francis, Paul André De Lame, William W. Parmley

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Enhanced external counterpulsation (EECP) treatment can improve exercise tolerance in patients with ischemic heart disease; however, the possible benefits of EECP in patients with stable heart failure (HF) and left ventricular dysfunction (LVD) are unclear. An open pilot study showed significant increases in exercise tolerance in HF patients undergoing EECP. Thus a larger, controlled study of EECP in patients with stable HF (New York Heart Association [NYHA] classes II and III) and LVD was undertaken. Methods and Results: The PEECH trial is a controlled, randomized, single-blind, parallel-group, multicenter study of 187 patients with symptomatic but stable HF (NYHA classes II and III) and an LV ejection fraction ≤35% was designed to assess the efficiency of EECP in patients with stable HF. Medical therapy is optimized in all patients based on the recommendations of the Heart Failure Society of America ("Usual Care"), and then randomized between 2 treatment groups; UC or EECP (35 hours over 7 weeks). Conclusion: Efficacy measures include standard exercise tolerance tests on a treadmill (modified Naughton protocol), with measurements of peak oxygen uptake and exercise duration time; quality of life questionnaires; NYHA classification; and neurohormonal markers of HF.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalJournal of cardiac failure
Volume11
Issue number3
DOIs
StatePublished - Apr 2005

Keywords

  • Clinical trial
  • Enhanced external counterpulsation
  • Heart failure

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