Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

Amy P. Chiu, Barbara R. Tschida, Lilian H. Lo, Branden S. Moriarity, Dewi K. Rowlands, David A. Largaespada, Vincent W. Keng

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The major type of human liver cancer is hepatocellular carcinoma (HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral (HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models to address the problems of liver cancer, especially HBVassociated HCC occurrences in Asia.

Original languageEnglish (US)
Pages (from-to)12157-12170
Number of pages14
JournalWorld journal of gastroenterology
Volume21
Issue number42
DOIs
StatePublished - Nov 14 2015

Keywords

  • Forward and reverse genetic screens
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Sleeping Beauty
  • Transposable elements

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