The scientific investigation of the organophosphate cholinesterase inhibitors began over a century ago and focused primarily on their actions at the neuromuscular synapse. In recent years, however, it has been recognized that major cholinergic pathways exist widely in the central nervous system (CNS) and that many of the immediate effects of this type of anticholinesterase are the result of actions on the CNS. To identify and describe the pathophysiological responses of the brain to acute OP exposure, it is useful to retain the normal brain vascular and cellular structures and to eliminate interferences from other tissues. This can be accomplished with perfused organ preparations. In this respect, seizure genesis, blood flow regulation and cellular alterations in perfused brain in response to cholinesterase inhibitors are presented.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Western Pharmacology Society|
|State||Published - Jan 1 1985|