TY - JOUR
T1 - Transplantation of discordant xenografts
T2 - a review of progress
AU - Platt, Jeffrey L.
AU - Vercellotti, Gregory M.
AU - Dalmasso, Agustin P.
AU - Matas, Arthur J.
AU - Bolman, R. Morton
AU - Najarian, John S.
AU - Bach, Fritz H.
PY - 1990
Y1 - 1990
N2 - Hyperacute rejection, apparently initiated by natural antibodies and complement, has been viewed as an absolute barrier to the xenotransplantation of vascularized grafts between different species. Until recently, little was known about the molecular and physiological basis for this barrier nor was there evidence that the barrier might be more than transiently breached. In this paper Jeffrey Platt, Fritz Bach and colleagues describe a model of hyperacute rejection and propose that, if hyperacute rejection can be averted for a period after transplantation, prolonged xenograft survival will be possible.
AB - Hyperacute rejection, apparently initiated by natural antibodies and complement, has been viewed as an absolute barrier to the xenotransplantation of vascularized grafts between different species. Until recently, little was known about the molecular and physiological basis for this barrier nor was there evidence that the barrier might be more than transiently breached. In this paper Jeffrey Platt, Fritz Bach and colleagues describe a model of hyperacute rejection and propose that, if hyperacute rejection can be averted for a period after transplantation, prolonged xenograft survival will be possible.
UR - http://www.scopus.com/inward/record.url?scp=0025225361&partnerID=8YFLogxK
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U2 - 10.1016/0167-5699(90)90174-8
DO - 10.1016/0167-5699(90)90174-8
M3 - Review article
C2 - 2073317
AN - SCOPUS:0025225361
VL - 11
SP - 450
EP - 456
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - C
ER -