Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies

Melena D. Bellin, Ty B. Dunn

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Whole-organ pancreas and islet transplantations are performed in a highly selected group of patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by recurrent severe hypoglycaemia or renal failure requiring kidney transplantation. Clinical accessibility to pancreases or islets, and patient characteristics and therapeutic goals, may dictate choice of procedure. Pancreas transplantation is most often performed simultaneous with a kidney transplant, but patients with particularly labile type 1 diabetes may be considered for a pancreas transplant alone. While highly successful at restoring insulin independence, pancreas transplants carry the significant risks of major surgery and immunosuppression. Islet transplantation is a relatively minor procedure, usually performed for labile type 1 diabetes with severe hypoglycaemia. It is highly successful at resolving hypoglycaemia, but more than one pancreas donor may be required for insulin independence. Both pancreas and islet transplantation are limited in applicability by a paucity of deceased donors. Pigs provide one promising replenishable source of islets. Porcine islets can successfully reverse diabetes mellitus in non-human primates under the appropriate immunosuppressive conditions, with promise for eventually translating this success to a larger population of patients with diabetes mellitus in the future. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)2049-2056
Number of pages8
JournalDiabetologia
Volume63
Issue number10
DOIs
StatePublished - Oct 1 2020

Bibliographical note

Funding Information:
MDB discloses the following conflicts of interest: research support from Viacyte and Dexcom; Data Safety Monitoring Board membership for Insulet. TBD declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

Keywords

  • Diabetes
  • Hypoglycaemia
  • Immunosuppression
  • Islet
  • Kidney
  • Pancreas
  • Transplant
  • Type 1 diabetes

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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