Transmission of chronic nociception by spinal neurons expressing the substance P receptor

Michael L. Nichols, Brian J. Allen, Scott D. Rogers, Joseph R. Ghilardi, Prisca Honore, Nancy M. Luger, Matthew P. Finke, Jun Li, Douglas A. Lappi, Donald A Simone, Patrick W. Mantyh

Research output: Contribution to journalArticlepeer-review

344 Scopus citations

Abstract

Substance P receptor (SPR)-expressing spinal neurons were ablated with the selective cytotoxin substance P-saporin. Loss of these neurons resulted in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropathic and inflammatory pain states. This loss appeared to be permanent. Responses to mildly painful stimuli and morphine analgesia were unaffected by this treatment. These results identify a target for treating persistent pain and suggest that the small population of SPR- expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.

Original languageEnglish (US)
Pages (from-to)1558-1561
Number of pages4
JournalScience
Volume286
Issue number5444
DOIs
StatePublished - Nov 19 1999

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