TY - JOUR
T1 - Transmission of anaplastic large cell lymphoma via organ donation after cardiac death
AU - Harbell, J. W.
AU - Dunn, Ty B
AU - Fauda, M.
AU - John, D. G.
AU - Goldenberg, A. S.
AU - Teperman, L. W.
PY - 2008/1
Y1 - 2008/1
N2 - Recently, donation after cardiac death (DCD) has been encouraged in order to expand the donor pool. We present a case of anaplastic T-cell lymphoma transmitted to four recipients of solid organ transplants from a DCD donor suspected of having bacterial meningitis. On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma. The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden. We recommend transplanting organs from donors with suspected bacterial meningitis only after identification of the infectious organism. In cases of lymphoma transmission, excision of the graft may be the only chance at long-term survival.
AB - Recently, donation after cardiac death (DCD) has been encouraged in order to expand the donor pool. We present a case of anaplastic T-cell lymphoma transmitted to four recipients of solid organ transplants from a DCD donor suspected of having bacterial meningitis. On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma. The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden. We recommend transplanting organs from donors with suspected bacterial meningitis only after identification of the infectious organism. In cases of lymphoma transmission, excision of the graft may be the only chance at long-term survival.
KW - Cardiac death donors
KW - Donation after cardiac death
KW - Liver transplantation
KW - Non-heart-beating donors
KW - Pancreas transplantation
KW - Renal transplantation
KW - T-cell lymphoma
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U2 - 10.1111/j.1600-6143.2007.02033.x
DO - 10.1111/j.1600-6143.2007.02033.x
M3 - Article
C2 - 18021286
AN - SCOPUS:37549032140
SN - 1600-6135
VL - 8
SP - 238
EP - 244
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 1
ER -
