Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system

Abdelkader Behdenna, Tiziana Lembo, Olga Calatayud, Sarah Cleaveland, Jo E.B. Halliday, Craig Packer, Felix Lankester, Katie Hampson, Meggan E Craft, Anna Czupryna, Andrew P. Dobson, Edward J. Dubovi, Eblate Ernest, Robert Fyumagwa, J. Grant C. Hopcraft, Christine Mentzel, Imam Mzimbiri, David Sutton, Brian Willett, Daniel T. Haydon & 1 others Mafalda Viana

Research output: Contribution to journalArticle

Abstract

Understanding multi-host pathogen maintenance and transmission dynamics is critical for disease control. However, transmission dynamics remain enigmatic largely because they are difficult to observe directly, particularly in wildlife. Here, we investigate the transmission dynamics of canine parvovirus (CPV) using state-space modelling of 20 years of CPV serology data from domestic dogs and African lions in the Serengeti ecosystem. We show that, although vaccination reduces the probability of infection in dogs, and despite indirect enhancement of population seropositivity as a result of vaccine shedding, the vaccination coverage achieved has been insufficient to prevent CPV from becoming widespread. CPV is maintained by the dog population and has become endemic with approximately 3.5-year cycles and prevalence reaching approximately 80%. While the estimated prevalence in lions is lower, peaks of infection consistently follow those in dogs. Dogs exposed to CPV are also more likely to become infected with a second multi-host pathogen, canine distemper virus. However, vaccination can weaken this coupling, raising questions about the value of monovalent versus polyvalent vaccines against these two pathogens. Our findings highlight the need to consider both pathogen- and host-level community interactions when seeking to understand the dynamics of multi-host pathogens and their implications for conservation, disease surveillance and control programmes.

Original languageEnglish (US)
Number of pages1
JournalProceedings. Biological sciences
Volume286
Issue number1899
DOIs
StatePublished - Mar 27 2019

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Canine Parvovirus
Carnivore protoparvovirus 1
Pathogens
Ecology
pathogen
Dogs
vaccination
ecology
pathogens
dogs
Lions
Vaccination
Panthera leo
vaccine
disease control
Vaccines
Canine Distemper Virus
vaccines
Disease control
Canine distemper virus

Keywords

  • coinfection
  • domestic–wildlife interface
  • longitudinal serology
  • maintenance host
  • state–space models
  • vaccine shedding

PubMed: MeSH publication types

  • Journal Article

Cite this

Behdenna, A., Lembo, T., Calatayud, O., Cleaveland, S., Halliday, J. E. B., Packer, C., ... Viana, M. (2019). Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system. Proceedings. Biological sciences, 286(1899). https://doi.org/10.1098/rspb.2018.2772

Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system. / Behdenna, Abdelkader; Lembo, Tiziana; Calatayud, Olga; Cleaveland, Sarah; Halliday, Jo E.B.; Packer, Craig; Lankester, Felix; Hampson, Katie; Craft, Meggan E; Czupryna, Anna; Dobson, Andrew P.; Dubovi, Edward J.; Ernest, Eblate; Fyumagwa, Robert; Hopcraft, J. Grant C.; Mentzel, Christine; Mzimbiri, Imam; Sutton, David; Willett, Brian; Haydon, Daniel T.; Viana, Mafalda.

In: Proceedings. Biological sciences, Vol. 286, No. 1899, 27.03.2019.

Research output: Contribution to journalArticle

Behdenna, A, Lembo, T, Calatayud, O, Cleaveland, S, Halliday, JEB, Packer, C, Lankester, F, Hampson, K, Craft, ME, Czupryna, A, Dobson, AP, Dubovi, EJ, Ernest, E, Fyumagwa, R, Hopcraft, JGC, Mentzel, C, Mzimbiri, I, Sutton, D, Willett, B, Haydon, DT & Viana, M 2019, 'Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system' Proceedings. Biological sciences, vol. 286, no. 1899. https://doi.org/10.1098/rspb.2018.2772
Behdenna, Abdelkader ; Lembo, Tiziana ; Calatayud, Olga ; Cleaveland, Sarah ; Halliday, Jo E.B. ; Packer, Craig ; Lankester, Felix ; Hampson, Katie ; Craft, Meggan E ; Czupryna, Anna ; Dobson, Andrew P. ; Dubovi, Edward J. ; Ernest, Eblate ; Fyumagwa, Robert ; Hopcraft, J. Grant C. ; Mentzel, Christine ; Mzimbiri, Imam ; Sutton, David ; Willett, Brian ; Haydon, Daniel T. ; Viana, Mafalda. / Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system. In: Proceedings. Biological sciences. 2019 ; Vol. 286, No. 1899.
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