Translocation of ligand conformational free energy in receptor activation: A possible functional role of conformational isomerism in drug action

P. S. Portoghese

doi:10.1002/jps.2600600537

Translocation of ligand conformational free energy in receptor activation: A possible functional role of conformational isomerism in drug action

P. S. Portoghese

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Original language	English (US)
Pages (from-to)	806-807
Number of pages	2
Journal	Journal of Pharmaceutical Sciences
Volume	60
Issue number	5
DOIs	https://doi.org/10.1002/jps.2600600537
State	Published - May 1971

Bibliographical note

Funding Information:
Received November 13, 1970. Minneapolis, MN 55455 Accepted for publication January 27, 1971. The author is indebted to Dr. Edward G. Rippie for helpful discussions. Supported in part by National Institutes of Health Grant GM- 09402.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

Conformation isomerism relationship—biological activity
Ligand conformational free energy—receptor activation

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title = "Translocation of ligand conformational free energy in receptor activation: A possible functional role of conformational isomerism in drug action",

keywords = "Conformation isomerism relationship—biological activity, Ligand conformational free energy—receptor activation",

author = "Portoghese, {P. S.}",

note = "Funding Information: Received November 13, 1970. Minneapolis, MN 55455 Accepted for publication January 27, 1971. The author is indebted to Dr. Edward G. Rippie for helpful discussions. Supported in part by National Institutes of Health Grant GM- 09402. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1971",

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language = "English (US)",

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pages = "806--807",

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AU - Portoghese, P. S.

N1 - Funding Information: Received November 13, 1970. Minneapolis, MN 55455 Accepted for publication January 27, 1971. The author is indebted to Dr. Edward G. Rippie for helpful discussions. Supported in part by National Institutes of Health Grant GM- 09402. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1971/5

Y1 - 1971/5

KW - Conformation isomerism relationship—biological activity

KW - Ligand conformational free energy—receptor activation

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JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

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Translocation of ligand conformational free energy in receptor activation: A possible functional role of conformational isomerism in drug action

Bibliographical note

Keywords

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