Translational control: A target for cancer therapy

Saritha C. Thumma, Robert A Kratzke

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety of novel therapeutics are in development targeting this mechanism as a treatment for cancer.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCancer Letters
Issue number1
StatePublished - Dec 8 2007


  • Cap-dependent
  • Translation
  • eIF4E
  • eIF4F


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