Translational control: A target for cancer therapy

Saritha C. Thumma, Robert A Kratzke

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety of novel therapeutics are in development targeting this mechanism as a treatment for cancer.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCancer Letters
Volume258
Issue number1
DOIs
StatePublished - Dec 8 2007

Keywords

  • Cap-dependent
  • Translation
  • eIF4E
  • eIF4F

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