Translational and clinical pharmacology considerations in drug repurposing for X-linked adrenoleukodystrophy—A rare peroxisomal disorder

Keyphrases

• X-linked 100%
• Clinical Pharmacology 100%
• Drug Repurposing 100%
• Peroxisomal Disorders 100%
• Translational Pharmacology 100%
• Disease Progression 40%
• Rare Diseases 40%
• X-linked Adrenoleukodystrophy (X-ALD) 40%
• Clinical Trials 20%
• Pharmacokinetics-pharmacodynamics (PK-PD) 20%
• Patient Demographics 20%
• Effective Therapy 20%
• Limited Treatment 20%
• Drug Development 20%
• Neurodegenerative 20%
• Clinical Experience 20%
• Demyelination 20%
• Repurposing 20%
• Site of Action 20%
• First Decade 20%
• Drug Candidates 20%
• Blindness 20%
• Drug Potential 20%
• Pharmacological Approaches 20%
• Small Clinical Trials 20%
• Causing Death 20%
• Disease Pathophysiology 20%
• Drug Pharmacology 20%
• Gait Disturbance 20%
• Drug-target Interaction 20%
• Spastic Quadriparesis 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Clinical Pharmacology 100%
• Disorders of Peroxisomal Functions 100%
• Drug Repositioning 100%
• Rare Disease 66%
• Disease 66%
• Adrenoleukodystrophy 66%
• Clinical Trial 33%
• Pharmacodynamics 33%
• Drug Development 33%
• Preclinical Study 33%
• Repurposing 33%
• Disease Exacerbation 33%
• Quadriplegia 33%
• Demyelination 33%
• Pathophysiology 33%
• Pharmacokinetics 33%