Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group

Elizabeth B. Yerkes, Earl Y. Cheng, John S. Wiener, J. Christopher Austin, Duong D. Tu, David B. Joseph, Jonathan C. Routh, Stacy T. Tanaka

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Pediatric patients present unique challenges in the performance and interpretation of urodynamic studies. Interpretation of urodynamics to guide clinical management at an institutional level is accepted as reliable. Challenges arise however when multi-site collaborations incorporate urodynamics into study design to determine primary or secondary outcomes or to direct decision-making. Although standardized terminology has been established by ICCS, the application of this shared language to performance and interpretation of pediatric urodynamics to across multiple sites may not be intuitive or reliable. With a primary goal of defining the care necessary to protect future renal function, the UMPIRE protocol (Urologic Management to Preserve Initial REnal function) utilizes a urodynamics-based risk stratification to determine medical management for infants with myelomeningocele. Iterative changes in the protocol are based upon the clinical progress of the enrolled children. Despite a team experienced in subtleties of urodynamics and despite efforts to minimize variability across sites, the UMPIRE study group identified several areas in which the language of urodynamics required additional clarification or creation of more explicit definitions to standardize performance and interpretation across sites. This article reviews the foundations of current urodynamics practice, describes limitations and challenges unique to pediatric studies, and the shares the humble lessons learned by the UMPIRE study group on their journey toward standardized urodynamic language for management of infants and children with myelomeningocele.

Original languageEnglish (US)
Pages (from-to)716-725
Number of pages10
JournalJournal of Pediatric Urology
Issue number5
StatePublished - Oct 2021
Externally publishedYes

Bibliographical note

Funding Information:
This paper would not have been possible without the prior work and insights of many people in the pediatric urology community, including the work cited in this paper and others. Rosalia Misseri (along with authors EYC, DBJ, JW, EBY) developed and revised the NSBPR risk categories. The UMPIRE urologic investigators from all ten sites transparently discussed the practices and practicalities of their institutions to shape the performance standards. Additionally, we thank the non-pediatric urology UMPIRE investigators (Michelle Baum, Bill Walker, Kathy Smith, Jonathan Castillo) who contributed their insights and patiently sat through long discussions focused solely on urodynamics.

Publisher Copyright:
© 2021


  • Bladder
  • Neurogenic
  • Pediatric
  • Standardization
  • Terminology
  • Urodynamics

PubMed: MeSH publication types

  • Journal Article
  • Review


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