Transition state theory for enzyme kinetics

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Abstract

This article is an essay that discusses the concepts underlying the application of modern transition state theory to reactions in enzymes. Issues covered include the potential of mean force, the quantization of vibrations, the free energy of activation, and transmission coefficients to account for nonequilibrium effect, recrossing, and tunneling.

Original languageEnglish (US)
Article number6979
Pages (from-to)10-17
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume582
DOIs
StatePublished - Sep 15 2015

Bibliographical note

Funding Information:
This work was supported in part by the National Institutes of Health through Grant No. NIGMS/1RC1GM091445 .

Publisher Copyright:
© 2015 Elsevier Inc.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Enzyme kinetics
  • Free energy
  • Quantum effects
  • Transition state theory
  • Tunneling

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