Transition state theory for enzyme kinetics

Donald G. Truhlar

doi:10.1016/j.abb.2015.05.004

Transition state theory for enzyme kinetics

Donald G. Truhlar

Chemistry (Twin Cities)

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

This article is an essay that discusses the concepts underlying the application of modern transition state theory to reactions in enzymes. Issues covered include the potential of mean force, the quantization of vibrations, the free energy of activation, and transmission coefficients to account for nonequilibrium effect, recrossing, and tunneling.

Original language	English (US)
Article number	6979
Pages (from-to)	10-17
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	582
DOIs	https://doi.org/10.1016/j.abb.2015.05.004
State	Published - Sep 15 2015

Bibliographical note

Funding Information:
This work was supported in part by the National Institutes of Health through Grant No. NIGMS/1RC1GM091445 .

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Enzyme kinetics
Free energy
Quantum effects
Transition state theory
Tunneling

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10.1016/j.abb.2015.05.004

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abstract = "This article is an essay that discusses the concepts underlying the application of modern transition state theory to reactions in enzymes. Issues covered include the potential of mean force, the quantization of vibrations, the free energy of activation, and transmission coefficients to account for nonequilibrium effect, recrossing, and tunneling.",

keywords = "Enzyme kinetics, Free energy, Quantum effects, Transition state theory, Tunneling",

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note = "Funding Information: This work was supported in part by the National Institutes of Health through Grant No. NIGMS/1RC1GM091445 . Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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KW - Free energy

KW - Quantum effects

KW - Transition state theory

KW - Tunneling

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Transition state theory for enzyme kinetics

Abstract

Bibliographical note

Keywords

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