Transition-metal-mediated routes to 3,3-disubstituted oxindoles through anilide cyclisation

Johannes Klein, Richard J.K. Taylor

Research output: Contribution to journalReview articlepeer-review

253 Scopus citations

Abstract

This review describes transition-metal-catalysed and -mediated processes for the preparation of oxindoles from anilides through C(3)-C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar-H coupling processes, are presented, as are applications in natural product synthesis.

Original languageEnglish (US)
Pages (from-to)6821-6841
Number of pages21
JournalEuropean Journal of Organic Chemistry
Issue number34
DOIs
StatePublished - Dec 1 2011

Keywords

  • C-H activation
  • Enolate arylations
  • Heck reaction
  • Natural product synthesis
  • Oxindoles
  • Synthesis
  • Transition metals

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