Transition-metal-mediated routes to 3,3-disubstituted oxindoles through anilide cyclisation

Johannes Klein; Richard J.K. Taylor

doi:10.1002/ejoc.201100836

Transition-metal-mediated routes to 3,3-disubstituted oxindoles through anilide cyclisation

Johannes Klein, Richard J.K. Taylor

Chemistry (Twin Cities)

Research output: Contribution to journal › Review article › peer-review

253 Scopus citations

Abstract

This review describes transition-metal-catalysed and -mediated processes for the preparation of oxindoles from anilides through C(3)-C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar-H coupling processes, are presented, as are applications in natural product synthesis.

Original language	English (US)
Pages (from-to)	6821-6841
Number of pages	21
Journal	European Journal of Organic Chemistry
Issue number	34
DOIs	https://doi.org/10.1002/ejoc.201100836
State	Published - Dec 1 2011

Keywords

C-H activation
Enolate arylations
Heck reaction
Natural product synthesis
Oxindoles
Synthesis
Transition metals

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abstract = "This review describes transition-metal-catalysed and -mediated processes for the preparation of oxindoles from anilides through C(3)-C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar-H coupling processes, are presented, as are applications in natural product synthesis.",

keywords = "C-H activation, Enolate arylations, Heck reaction, Natural product synthesis, Oxindoles, Synthesis, Transition metals",

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AB - This review describes transition-metal-catalysed and -mediated processes for the preparation of oxindoles from anilides through C(3)-C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar-H coupling processes, are presented, as are applications in natural product synthesis.

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KW - Heck reaction

KW - Natural product synthesis

KW - Oxindoles

KW - Synthesis

KW - Transition metals

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Transition-metal-mediated routes to 3,3-disubstituted oxindoles through anilide cyclisation

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