Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest

Ali Nakhi, Md Shafiqur Rahman, Guru Pavan Kumar Seerapu, Rakesh Kumar Banote, Kummari Lalith Kumar, Pushkar Kulkarni, Devyani Haldar, Manojit Pal

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A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)4930-4934
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number30
StatePublished - Aug 14 2013
Externally publishedYes

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