A transition metal-free, regioselective C-5 trifluoromethylation of 2,3-dihydropyridin-4(1H)- ones (cyclic enaminones) with trimethyl(trifluoromethyl) silane (TMSCF3) was developed that proceeds under mild conditions at room temperature. This direct transformation was successful with both electron-rich and electron-deficient cyclic enamin- ACHTUNGTRENUNGones. This method bypasses substrate prefunctionalization and transition metal catalysis, and allows the convenient and direct access to a variety of medicinally important 3-trifluoromethylpiperidine derivatives. This chemistry also represents a rare example of a direct trifluoromethylation of an internal olefinic C-H bond. A radical mechanism is proposed for this reaction.
|Original language||English (US)|
|Number of pages||9|
|Journal||Advanced Synthesis and Catalysis|
|State||Published - Nov 24 2014|
Bibliographical notePublisher Copyright:
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
- C-H activation