Transition metal-catalyzed regio- and stereoselective aminobromination of olefins with TsNH2 and NBS as nitrogen and bromine sources

Vinay V. Thakur, Siva Kumar Talluri, A. Sudalai

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

(Matrix presented) A new synthetic procedure for aminohalogenation of olefins has been developed for the preparation of vicinal haloamine derivatives in high yields by using Cu, Mn, or V catalysts with p-toluenesulfonamide (TsNH2) and N-bromosuccinimide (NBS) as nitrogen and bromine sources, respectively. Unprecedented regio- and stereoselectivity (anti:syn > 99:1) toward the aminohalogenation process is shown for olefinic substrates as well as transition metal catalysts.

Original languageEnglish (US)
Pages (from-to)861-864
Number of pages4
JournalOrganic Letters
Volume5
Issue number6
DOIs
StatePublished - Mar 20 2003

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