Transient free radicals are formed during photolysis of the 1-(2-nitrophenyl)ethyl ester of adenosine triphosphate (caged ATP)

John E.T. Corrie, Josh Baker, Michael E. Ostap, David D Thomas, David R. Trentham

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Abstract

Flash photolysis of the P3-1-(2-nitrophenyl)ethyl ester of ATP (caged ATP) in the presence of dithiothreitol results in formation of a transient radical species in addition to the known paired-electron aci-nitro anion. The transient radical represents approx. 10% of the reaction flux and is proposed to be the radical anion of the nitroaryl group of caged ATP. The kinetics of its formation suggest that it arises by single electron transfer to the triplet excited state of the nitroarene. The electron donor has not been conclusively identified but tertiary amines present as buffer salts or as impurities are likely candidates.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume115
Issue number1
DOIs
StatePublished - May 15 1998

Bibliographical note

Funding Information:
We thank Professor B.C. Gilbert for permissiont o report the results of experiments carried out in his laboratory and Dr. A.C. Whitwood for help with those experiments. We are grateful to Milena Higgins and John Stamm for performing the ATP assays.T his work was supported in part by NIH Grant AR32961 ( to D.D.T. ).

Keywords

  • Adenosine triphosphate
  • Photolysis
  • Transient free radicals

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