Transient alteration in intestinal permeability to technetium Tc99m diethylenetriaminopentaacetate during the prodromal stages of alimentary laminitis in ponies

Douglas J. Weiss, Oral A. Evanson, Jennifer MacLeay, David R Brown

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objectives - To determine whether mucosal permeability is altered during the prodromal stages of alimentary laminitis. Animals - 15 healthy adult ponies. Procedures - Intestinal permeability was evaluated for control ponies (n = 5) and for ponies 4 to 12 (n = 5) and 20 to 28 (n = 5) hours after administration of carbohydrate overload. Mucosal permeability was determined by measuring the percentage of orally administered technetium Tc99m diethylenetriaminopentaacetate ((99m)Tc-DTPA) excreted in urine during an 8- hour period, then measuring blood radioactivity at hourly intervals. Plasma endotoxin-like activity was measured by use of a chromogenic Limulus amebocyte assay. Results - Urinary excretion of (99m)Tc-DTPA was 2.45% of administered dose for control ponies, and was 16.67% of administered dose 4 to 12 hours and 3.57% of administered dose 20 to 28 hours after administration of carbohydrate. Conclusions - A marked but transient increase in intestinal permeability was observed early in the prodromal stages of alimentary laminitis. Clinical Relevance - Absorption of substances from the intestine may be an initiating event in alimentary laminitis.

Original languageEnglish (US)
Pages (from-to)1431-1434
Number of pages4
JournalAmerican journal of veterinary research
Volume59
Issue number11
StatePublished - Nov 1 1998

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