Transglutaminase and receptor-mediated endocytosis in macrophages and cultured fibroblasts

Peter J.A. Davies, Michael P. Murtaugh

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The function of intracellular transglutaminases remains to be clarified. In fibroblasts the links between the activity of this enzyme and receptor-mediated endocytosis are complex and open to interpretation. However, the issue cannot be firmly laid to rest until the structural specificity of the alkylamine inhibitors of endocytosis is explained. In macrophages, there is substantial evidence that the enzyme plays some role in receptor-mediated phagocytosis, but what this role is and how it might relate to endocytosis in other types of cells is at present an unresolved issue.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalMolecular and cellular biochemistry
Volume58
Issue number1-2
DOIs
StatePublished - Mar 1 1984

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