Transgenic models of neurodegenerative diseases

Michael K. Lee, David R. Borchelt, Philip C. Wong, Sangram S. Sisodia, Donald L. Price

Research output: Contribution to journalArticle

20 Scopus citations


Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinucleotide repeat diseases, result from a gain of deleterious properties. The disease-specific pathology in transgenic mice demonstrates the utility of these models in elucidating pathogenic mechanisms of the disease and in developing therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)651-660
Number of pages10
JournalCurrent opinion in neurobiology
Issue number5
StatePublished - Oct 1996

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    Lee, M. K., Borchelt, D. R., Wong, P. C., Sisodia, S. S., & Price, D. L. (1996). Transgenic models of neurodegenerative diseases. Current opinion in neurobiology, 6(5), 651-660.