Transgenic models of α-synucleinopathy

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Parkinson’s disease (PD) is a common late-onset, progressive neurodegenerative disease characterized by selective loss of neuronal populations, including dopaminergic (DAergic) neurons of substantia nigra, pars compacta (SNpc), and presence of fibrillar, cytoplasmic inclusions called Lewy bodies (LBs) and Lewy neurites (LNs) (1). While degeneration of dopamine (DA) neurons is responsible for much of the motoric symptoms of PD, neuropathology in PD extends well beyond the DAergic systems (2,3). Significantly, non-DAergic pathology may precede DAergic pathology in PD (2,3).

Original languageEnglish (US)
Title of host publicationParkinson's Disease
Subtitle of host publicationGenetics and Pathogenesis
PublisherCRC Press
Pages251-268
Number of pages18
ISBN (Electronic)9781420019223
ISBN (Print)9780849336973
StatePublished - Jan 1 2007
Externally publishedYes

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