Transfusion of uncrossmatched group o erythrocyte-containing products does not interfere with most ABO typings

Biomedical Excellence for Safer Transfusion Collaborative

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This study investigated the impact of transfusing increasing numbers of uncrossmatched type O products on the recipient's first in-hospital ABO type. Methods: This was a retrospective cohort study. Results of the first ABO type obtained in adult, non-type O recipients (i.e., types A, B, AB) after receiving at least one unit of uncrossmatched type O erythrocyte-containing product(s) for any bleeding etiology were analyzed along with the number of uncrossmatched type O erythrocyte-containing products administered in the prehospital and/or in hospital setting before the first type and screen sample was drawn. results: There were 10 institutions that contributed a total of 695 patient records. Among patients who received up to 10 uncrossmatched type O erythrocyte-containing products, the median A antigen agglutination strength in A and AB individuals on forward typing (i.e., testing the recipient's erythrocytes for A and/or B antigens) was the maximum (4+), whereas the median B antigen agglutination strength among B and AB recipients of up to 10 units was 3 to 4+. The median agglutination strength on the reverse type (i.e., testing the recipient's plasma for corresponding anti-A and -B antibodies) was very strong, between 3 and 4+, for recipients of up to 10 units of uncrossmatched erythrocyte-containing products. Overall, the ABO type of 665 of 695 (95.7%; 95% CI, 93.9 to 97.0%) of these patients could be accurately determined on the first type and screen sample obtained after transfusion of uncrossmatched type O erythrocyte-containing products. conclusions: The transfusion of smaller quantities of uncrossmatched type O erythrocyte-containing products, in particular up to 10 units, does not usually interfere with determining the recipient's ABO type. The early collection of a type and screen sample is important.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalAnesthesiology
Volume132
Issue number3
DOIs
StatePublished - Mar 2020

Bibliographical note

Publisher Copyright:
© 2019, the American Society of Anesthesiologists, Inc. All Rights Reserved. Anesthesiology 2020; 132:525-34.

Keywords

  • ABO Blood-Group System
  • Adult
  • Agglutination
  • Blood Grouping and Crossmatching/methods
  • Blood Transfusion/methods
  • Cohort Studies
  • Emergency Medical Services
  • Erythrocyte Transfusion/methods
  • Hemorrhage/therapy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Wounds and Injuries/therapy

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Multicenter Study
  • Journal Article

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