Transformation of Steroids by Algae

Yusuf J Abul-Hajj, Xiadong Qian

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Twenty-two algal cultures grown photoautotrophically were incubated with 4-androstene-3,17-dione and 17β-hydroxy-4-androstene-3-one. Most cultures were capable of effecting transformation. The metabolites were isolated and detected by tic and hplc, and were identified by comparison of chromatographic and/or spectral properties with those of authentic compounds. Most cultures showed the presence of 17-oxidoreductase, some were capable of hydroxylating 4-androstenedione at the 6β- and l4α-positions, and a few were capable of utilizing substrates as an energy and/or a carbon source. Incubations with testosterone showed very little metabolism.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalJournal of Natural Products
Volume49
Issue number2
DOIs
StatePublished - Jan 1 1986

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